In this study, the effect of rolling angle orientation namely; 0, 45, and 90 degrees, and three rolling passes on the mechanical behavior of Al-Cu after vanadium addition were investigated. Al-4%Cu and Al-4%Cu-0.1%V sheets were produced and rolled from 4 mm to 3 mm followed by 3 to 2 mm, and finally from 2 mm to 1.3 mm. After each pass, the tensile test was performed in three directions from which the maximum tensile force, deformation energy, microhardness, and average surface roughness (Ra) were determined. A pronounce finding is that the addition of both additions of 0.1% vanadium to Al-4%Cu alloy and multi-rolling passes resulted in reducing the deformation energy by 85.4, and the maximum tensile forces reduced by 56.6%, this resulted in reduction of production cost of AlCuV alloys, furthermore, it resulted in reducing the anisotropy of AlCuV alloy. Additionally, the average microhardness was enhanced for Al-Cu and AlCuV alloy, whereas the Ra was in maximum enhanced for AlCuV alloy of about 64.9%.