Due to the costs, the unexpected appearance of graffiti on rail vehicles and the need to remove it is an increasingly serious problem for rail carriers. The use of anti-graffiti protective coatings by rail companies is becoming more and more common. These coatings must meet appropriate quality requirements, in particular regarding their mechanical properties and features, such as roughness, adhesion. The use of anti-graffiti coatings is also associated with the technology of their production and removal, taking into account the problem of environmental impact and costs. Some of the anti-graffiti coating systems were tested and compared. Anti-graffiti coating systems were characterized by low parameters of the geometric structure of the surface and good adhesion. Moreover, they had good mechanical properties and were free of structural defects as pores or microcracks. Anti-graffiti paint systems were characterized by hydrophobicity, which helps reduce the adhesion of undesirable substances on their surfaces. Also discussed are various aspects of the costs incurred by railway companies due to the existence and removal of graffiti from passenger cars. Economic analyses included data from Polish and Spanish national and regional railway companies.