This paper details the development and characterization of a photocatalytic efficacy test stand that was designed in response to an urgent global requirement for efficient and economically viable methods of pathogen elimination, such as the COVID-19 pandemic. The primary objective was to establish a robust methodology for evaluating the performance of a new type of device integrating an innovative photocatalytic antimicrobial core. This core is based on a specially engineered polypropylene fabric, active under normal illumination, which generates reactive oxygen species (ROS) for the destruction of pathogens, including viral agents. The design of the test stand was precisely engineered in SolidWorks and is protected by a utility model. The stand allows quantitative assessment of photocatalytic degradation by monitoring the concentration of toluene as a model volatile organic compound via a mass spectrometer. This system verifies the significant oxidation capacity and broad-spectrum potential of the test material for effective decontamination of the air environment. The developed test stand represents a versatile tool for further research and optimization of photocatalytic materials and is suitable for testing efficacy against both organic and inorganic compounds. It thus contributes to a major improvement in the quality of the indoor environment and the protection of public health.