Because of their superior mechanical, biodegradable, and biocompatible qualities, zinc-based alloys have drawn greater concentration on biodegradable metals. In this study, manganese was added to a Zn-1Mg alloy at different levels (0.2, 0.3, and 0.4 wt.%). The alloys were prepared via the powder metallurgy technique. The chemical composition, phase distribution, and microstructural characteristics of the Zn-1Mg alloys were evaluated before and after Mn addition. Additionally, the corrosion behavior of the alloys was investigated in Hank’s solution, and their Vickers microhardness was measured. Furthermore, biological performance evaluations, including contact angle and bioactivity tests, were conducted to assess the suitability of these alloys for implant applications. Overall, the study demonstrates that varying amounts of Mn addition hold significant potential for improving the hardness, corrosion resistance, and biological properties of Zn-1Mg alloys. Through metallographic observation OM, XRD, and SEM analysis of the alloy, it was found that Mn addition to the Zn-1Mg alloy resulted in the formation of the α-Zn matrix and Mg2Zn11 phase. The B3 alloy exhibited the highest hardness of 86.21 HV, compared with 66.09 HV for the base alloy. The maximum compressive strength was recorded for the B3 alloy, reaching 115 MPa. Mn addition improved corrosion resistance, reducing the corrosion rate to 0.099 mm/y for the B2 alloy, corresponding to an improvement of 87.126%; the contact angle decreased after Mn addition, indicating improved surface wettability. The outcomes showed that the addition of Mn significantly improved the bioactivity behavior of the samples under study; SEM images after immersion revealed a greater formation of HA particles on the surfaces of the Mn-added alloys compared with the base alloy. Different Mn contents were found to be optimal for different properties; 0.3 wt.% Mn provided the best corrosion resistance, whereas 0.4 wt.% Mn exhibited the highest hardness, compressive strength, and surface wettability.