Research on heat exchange is being carried out for more than five decades because of its importance in process industries and power generation plants. Heat exchanger experiencing cross flow are vulnerable to flow induced vibration. These vibration causes the interaction of tubes with the baffle resulting in a fretting wear of the tubes. Present study focuses on the fretting wear analysis of different tube materials. Fretting wear tests were performed on aluminum, copper and stainless steel instrumented central tubes against mild steel baffle. For each tube material the tests were performed for three different test durations i.e. 60 minutes, 120 minutes and 180 minutes at a cross flow velocity of 0.55 m/s. It was observed that vibrational amplitude of the flexible test tube is affected by its weight. A scanning electron microscope was used to analyze and measure the sizes of wear scar. The results indicated that wear loss in case of aluminum tube is the highest while that in case of stainless steel tube is the lowest.