Titanium and its alloys are nowadays broadly used in medical and advanced technical applications. Besides their corrosion resistance, lightweight, and durability, they exhibit relatively low hardness and wear resistance, as well as only weak bioactivity. Among the particularly promising titanium materials, the Ti6Al4V alloy is still the most widely applied in implantology. In the present research, this Ti alloy was subjected to mechanical grinding followed by laser irradiation with varying parameters, such as pulse laser power, pulse frequency, and scan rate. The topography determined by roughness and waviness, hydrophilicity determined by water contact angle, microhardness on the surface and within the created remelted surface layer, and corrosion resistance were determined. The roughness, waviness, and microhardness became greater with increasing scan rates, 7.5 mm/s and more. The water contact angle was scarcely affected by laser modification parameters, remaining close to 85º. The corrosion resistance was improved after laser irradiation, regardless of the laser parameters. Analyzing all applied laser treatment parameters and obtained results, it can be concluded that the most convenient modified surface can be achieved for the Ti6Al4V alloy at a laser power of 2000 W, a frequency of 25 Hz, and a scan rate of 7.5 mm/s. This positive result can be attributed to the melting and remelting processes occurring within the thin surface layer, substantially related to the delivered thermal energy, maximum temperature, diffusion, and rapid solidification of the layer.